Nitric oxide and platelet energy metabolism.
نویسندگان
چکیده
منابع مشابه
Nitric oxide and platelet energy metabolism.
This study was undertaken to determine whether nitric oxide (NO) can affect platelet responses through the inhibition of energy production. It was found that NO donors: S-nitroso-N-acetylpenicyllamine, SNAP, (5-50 microM) and sodium nitroprusside, SNP, (5-100 microM) inhibited collagen- and ADP-induced aggregation of porcine platelets. The corresponding IC50 values for SNAP and SNP varied from ...
متن کاملNitric oxide, energy metabolism and neurological disease.
Nitric oxide, energy metabolism and neurological disease S. J. R. Heales*t§, J. E. Barkert, V. C. Stewartt, M. P. Brandt, 1. P. HargreavesV, P. Foppa*((, J. M. Land*t, J. B. Clarkt and J. P. BolahosS 'Department of Clinical Biochemistry, National Hospital for Neurology and Neurosurgery, Queen Square, London WC I N 3BG, U.K., fDepartment of Neurochemistry, Institute of Neurology, Queen Square, L...
متن کاملNitric oxide and oxygen metabolism.
Introduction Inhibition of mitochondrial respiration has been associated with the cytotoxicity of NO right from the beginning of NO research [1,2]. Recent findings have confirmed the importance of mitochondrial inhibition, but put the previous research into a new context. Here we review our findings that: (a) NO reversibly inhibits O2 consumption by isolated cytochrome oxidase, mitochondria, ne...
متن کاملPlatelet-derived nitric oxide signaling and regulation.
Nitric oxide (NO) exerts important vasodilatory, antiplatelet, antioxidant, antiadhesive, and antiproliferative effects. Although endothelium derived NO has been shown to be of prime importance in cardio- and vasculoprotection, until recently little was known about the role of platelet-derived NO. New evidence suggests that NO synthesized by platelets regulates platelet functions, in particular...
متن کاملNitric oxide metabolism in wounds.
Arginine can be metabolized in wounds to nitric oxide and citrulline by nitric oxide synthase or to urea and ornithine by arginase. We investigated the expression of these arginine metabolic pathways over a 3-week period. Groups of 8-10 male Balb/C mice underwent a dorsal skin incision and subcutaneous polyvinyl alcohol sponge implantation. The animals were sacrificed at various times, and spon...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Acta Biochimica Polonica
سال: 2004
ISSN: 1734-154X,0001-527X
DOI: 10.18388/abp.2004_3562